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Pathology gallery 1

Hodgkins lymphoma

This slide shows a Reed-Sternberg cell typical of the nodular sclerosing form of Hodgkin's lymphoma.  This usually presents in adolescence and young adults as painless lymphadenopathy most commonly in the cervical nodes. The other histological forms (Rye Classification) include lymphocyte predominant, lymphocyte deplete and mixed cellularity.  Nodular sclerosing Hodgkin's disease has the worst prognosis.

 

Lobular carcinoma in-situ

This slide shows lobular carcinoma in-situ of the breast.  It is usually asymptomatic and mammographically occult.  It is an incidental finding in benign breast biopsies performed for other reasons.  Its significance lies in the fact that it increases the risk of breast cancer by a factor of approximately five-fold in both ipsilateral and contralateral breast.

 

Papillary carcinoma of the thyroid

This slide shows papillary carcinoma of the thyroid.  It has am increased incidence in iodine-rich areas and in those who have received neck irradiation.  It typically spreads to the lymph nodes.  The classical histological features are Psammoma bodies (arrow) and Orphan Annie cells.  The tumours are often described as minimal (< 1 cm diameter), intra-thyroid and extra-thyroid.  The tumours are often multifocal.

Ulcerative colitis

This slide is a low-power view of colonic wall showing an acute inflammatory infiltrate of the mucosa and submucosa.  There is no fissuring or granulomas. There is loss of the surface epithelium.  The diagnosis is that of ulcerative colitis.

 
 

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